Dutasteride spironolactone transgender

July 22, , I don't think block testosterone from the adrenals from reaching the T receptors. Its like and orchi basicly. Very expensive, hope you got insurance.
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The Case Against Spironolactone

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The Case Against Spironolactone – MTF Trans Hormonal Therapy

I'm new here and this is my first post. Thank you for the invitation to your group. Some of you may have seen my posts on Susan's Place, but it's difficult to discuss HRT without mentioning dosage, so I really appreciate this resource you have setup here. Stealthy closet cross dresser since childhood Turned 40 April and decided to take myself and my clothes out of the closet.
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Hormonal Treatment of Transgender Women with Oral Estradiol

Maintaining cross-sex hormone levels in the normal physiologic range for the desired gender is the cornerstone of transgender hormonal therapy, but there are limited data on how to achieve this. We investigated the effectiveness of oral estradiol therapy in achieving this goal. We analyzed data on all transgender females seen in our clinic since treated with oral estradiol. Nearly a third of patients did not achieve adequate treatment goals on 6 or even 8 mg daily of estradiol. Spironolactone did not enhance testosterone suppression, and finasteride was associated with higher testosterone levels.
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However, the drug has a number of mild to severe mental side effects, can lead to bodily changes which most trans women might consider disfiguring, and may interfere with breast development and other feminization. The use of Estradiol alone, without any kind of antiandrogen, is well known to be capable of suppressing testosterone to female levels. Ref 6 Studies at the time unfairly lumped all estrogens together, and all progestins together, as having the same dangers, a mistake which still lingers today.
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