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High molecular weight hyaluronan mediates the cancer resistance of the naked mole-rat

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This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole-rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4 years 4 , 5. In addition to their longevity, naked mole-rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer 2 , 6. We found that naked mole-rat fibroblasts secrete extremely high molecular weight hyaluronan HA , which is over five times larger than human or mouse HA.
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Genome sequencing reveals insights into physiology and longevity of the naked mole rat.

Genome sequencing reveals insights into physiology and longevity of the naked mole rat. The naked mole rat Heterocephalus glaber is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent.
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