Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model. Recent studies have revealed that platelet-derived growth factor PDGF plays a role in promoting progressive tumor growth in several organs; however, whether PDGF plays such a role in gastric carcinoma is undetermined. We examined whether inhibition of PDGF receptor PDGF-R tyrosine kinase signaling by imatinib affects tumor growth and metastasis in an orthotopic nude mouse model of human gastric carcinoma. TMK-1 human gastric carcinoma cells were injected into the gastric wall of nude mice. Tumor growth and metastasis were assessed. Resected tumors were analyzed immunohistochemically.
Curvy Erotic - Busty and curvy nude art model blog
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